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The impact of radiotherapy late effects on quality of life in gynaecological cancer patients

机译：放射治疗后期影响对妇科癌症患者生活质量的影响

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The aims of this study were to assess changes in quality of life (QoL) scores in relation to radical radiotherapy for gynaecological cancer (before and after treatment up to 3 years), and to identify the effect that late treatment effects have on QoL. This was a prospective study involving 225 gynaecological cancer patients. A QoL instrument (European Organisation for the Research and Treatment of Cancer QLQ-C30) and late treatment effect questionnaire (Late Effects Normal Tissues – Subjective Objective Management Analysis) were completed before and after treatment (immediately after radiotherapy, 6 weeks, 12, 24 and 36 months after treatment). Most patients had acute physical symptoms and impaired functioning immediately after treatment. Levels of fatigue and diarrhoea only returned to those at pre-treatment assessment after 6 weeks. Patients with high treatment toxicity scores had lower global QoL scores. In conclusion, treatment with radiotherapy for gynaecological cancer has a negative effect on QoL, most apparent immediately after treatment. Certain late treatment effects have a negative effect on QoL for at least 2 years after radiotherapy. These treatment effects are centred on symptoms relating to the rectum and bowel, for example, diarrhoea, tenesmus and urgency. Future research will identify specific symptoms resulting from late treatment toxicity that have the greatest effect on QoL; therefore allowing effective management plans to be developed to reduce these symptoms and improve QoL in gynaecological cancer patients.
机译：这项研究的目的是评估与妇科癌症根治性放疗相关的生活质量（QoL）评分的变化（治疗前后（长达3年）），并确定晚期治疗对QoL的影响。这是一项涉及225名妇科癌症患者的前瞻性研究。在治疗前后（放疗后，6周，12、24天）完成了QoL仪器（欧洲癌症研究和治疗组织QLQ-C30）和后期治疗效果调查表（后期效果正常组织–主观目标管理分析）。和治疗后36个月）。大多数患者在治疗后立即出现急性身体症状，并且功能受损。疲劳和腹泻的水平仅在6周后恢复到治疗前评估的水平。具有较高治疗毒性评分的患者具有较低的总体QoL评分。总之，妇科癌症放疗的治疗对QoL有负面影响，在治疗后最明显。放疗后至少2年，某些后期治疗效果会对QoL产生负面影响。这些治疗效果集中在与直肠和肠有关的症状上，例如腹泻，里急后重和紧迫感。未来的研究将确定由后期治疗毒性引起的对QoL影响最大的特定症状。因此，允许制定有效的管理计划以减轻这些症状并改善妇科癌症患者的生活质量。

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